Specific Brain Networks Related to the Symptoms of Obsessive-Compulsive Disorder

Self and other body perception in anorexia nervosa: The role of posterior DMN nodes

E Via, X Goldberg, I Sánchez, L Forcano, BJ Harrison, CG Davey, J Pujol, I Martínez-Zalacaín, F Fernández-Aranda, C Soriano-Mas, N Cardoner, JM Menchón

2018-04-03

Objectives: Body image distortion is a core symptom of anorexia nervosa (AN), which involves alterations in self- (and other’s) ev..

Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder

M Giménez, A Guinea-Izquierdo, V Villalta-Gil, I Martínez-Zalacaín, C Segalàs, M Subirà, E Real, J Pujol, BJ Harrison, JM Haro, JR Sato, MQ Hoexter, N Cardoner, P Alonso, JM Menchón, C Soriano-Mas

2017-12-01

The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Al..

Attenuated frontal and sensory inputs to the basal ganglia in cannabis users

L Blanco-Hinojo, J Pujol, BJ Harrison, D Macià, A Batalla, S Nogué, M Torrens, M Farré, J Deus, R Martín-Santos

2017-07-01

Heavy cannabis use is associated with reduced motivation. The basal ganglia, central in the motivation system, have the brain's hi..

Anomalous basal ganglia connectivity and obsessive– compulsive behaviour in patients with prader Willi syndrome

J Pujol, L Blanco-Hinojo, S Esteba-Castillo, A Caixàs, BJ Harrison, M Bueno, J Deus, M Rigla, D Macià, J Llorente-Onaindia, R Novell-Alsina

2016-07-01

Background: Prader Willi syndrome is a genetic disorder with a behavioural expression characterized by the presence of obsessive– ..

Neurodevelopmental correlates of proneness to guilt and shame in adolescence and early adulthood

S Whittle, K Liu, C Bastin, BJ Harrison, CG Davey

2016-06-01

Investigating how brain development during adolescence and early adulthood underlies guilt- and shame-proneness may be important f..

DISTINCT ETIOLOGICAL INFLUENCES on OBSESSIVE-COMPULSIVE SYMPTOM DIMENSIONS: A MULTIVARIATE TWIN STUDY

C López-Solà, LF Fontenelle, B Verhulst, MC Neale, JM Menchón, P Alonso, BJ Harrison

2016-03-01

Background Obsessive-compulsive disorder (OCD) is characterized by five major dimensions, including contamination/washing, harm/ch..

Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting

IH Harding, BJ Harrison, M Breakspear, C Pantelis, M Yücel

2016-02-01

Cognitive control (CC) and working memory (WM) are concurrently necessary for adaptive human behavior. These processes are thought..

Aetiological overlapbetweenobsessive-Compulsive related and anxiety disorder symptoms: Multivariate twin study

C López-Solà, LF Fontenelle, M Bui, JL Hopper, C Pantelis, M Yücel, JM Menchón, P Alonso, BJ Harrison

2016-01-01

Background The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including obsessive-compulsive disorde..

Brain functional correlates of emotion regulation across adolescence and young adulthood

K Stephanou, CG Davey, R Kerestes, S Whittle, J Pujol, M Yücel, A Fornito, M López-Solà, BJ Harrison

2016-01-01

Few studies have examined the neural correlates of emotion regulation across adolescence and young adulthood. Existing studies of ..

Functional connectivity bias in the prefrontal cortex of psychopaths

O Contreras-Rodríguez, J Pujol, I Batalla, BJ Harrison, C Soriano-Mas, J Deus, M López-Solà, D Macià, V Pera, R Hernández-Ribas, J Pifarré, JM Menchón, N Cardoner

2015-11-01

Background Psychopathy is characterized by a distinctive interpersonal style that combines callous-unemotional traits with inflexi..

A neural mediator of human anxiety sensitivity

BJ Harrison, MA Fullana, C Soriano-Mas, E Via, J Pujol, I Martínez-Zalacaín, D Tinoco-Gonzalez, CG Davey, M López-Solà, V Pérez Sola, JM Menchón, N Cardoner

2015-10-01

Advances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that hum..

Abnormal social reward responses in anorexia nervosa: An fmri study

E Via, C Soriano-Mas, I Sánchez, L Forcano, BJ Harrison, CG Davey, J Pujol, I Martínez-Zalacaín, JM Menchón, F Fernández-Aranda, N Cardoner

2015-07-21

Patients with anorexia nervosa (AN) display impaired social interactions, implicated in the development and prognosis of the disor..

Mapping the relationship between subgenual cingulate cortex functional connectivity and depressive symptoms across adolescence

C Strikwerda-Brown, CG Davey, S Whittle, NB Allen, ML Byrne, OS Schwartz, JG Simmons, D Dwyer, BJ Harrison

2015-07-21

Changes in the functional connectivity of the subgenual anterior cingulate cortex (SGC) have been linked with depressive symptoms...

Discrete alterations of brain network structural covariance in individuals at ultra-high risk for psychosis

K Heinze, RLEP Reniers, B Nelson, AR Yung, A Lin, BJ Harrison, C Pantelis, D Velakoulis, PD McGorry, SJ Wood

2015-06-01

Background Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse ..

Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression

CG Davey, S Whittle, BJ Harrison, JG Simmons, ML Byrne, OS Schwartz, NB Allen

2015-04-15

Background. The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affec..

Effective connectivity within the frontoparietal control network differentiates cognitive control and working memory

IH Harding, M Yücel, BJ Harrison, C Pantelis, M Breakspear

2015-02-01

Cognitive control and working memory rely upon a common fronto-parietal network that includes the inferior frontal junction (IFJ),..

A selective involvement of putamen functional connectivity in youth with internet gaming disorder

SB Hong, BJ Harrison, O Dandash, EJ Choi, SC Kim, HH Kim, DH Shim, CD Kim, JW Kim, SH Yi

2015-01-01

Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a re..

Functional dysconnectivity of corticostriatal circuitry and differential response to methylphenidate in youth with attention-deficit/hyperactivity disorder

SB Hong, BJ Harrison, A Fornito, CH Sohn, IC Song, JW Kim

2015-01-01

Background: Brain frontostriatal circuits have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder ..

Selective augmentation of striatal functional connectivity following NMDA receptor antagonism: Implications for psychosis

O Dandash, BJ Harrison, R Adapa, R Gaillard, F Giorlando, SJ Wood, PC Fletcher, A Fornito

2015-01-01

The psychotomimetic effect of the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine is thought to arise from a functional ..

Specific functional connectivity alterations of the dorsal striatum in young people with depression

R Kerestes, BJ Harrison, O Dandash, K Stephanou, S Whittle, J Pujol, CG Davey

2015-01-01

Background Altered basal ganglia function has been implicated in the pathophysiology of youth Major Depressive Disorder (MDD). Stu..

The neural cascade of olfactory processing: A combined fMRI-EEG study

Y Masaoka, IH Harding, N Koiwa, M Yoshida, BJ Harrison, V Lorenzetti, M Ida, M Izumizaki, C Pantelis, I Homma

2014-12-01

Olfaction is dependent on respiration for the delivery of odorants to the nasal cavity. Taking advantage of the time-locked nature..

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): Study protocol for a randomised control trial

CG Davey, AM Chanen, SM Cotton, SE Hetrick, MJ Kerr, M Berk, OM Dean, K Yuen, M Phelan, A Ratheesh, MR Schäfer, GP Amminger, AG Parker, D Piskulic, S Harrigan, AJ Mackinnon, BJ Harrison, PD McGorry

2014-11-04

Background: The aim of the Youth Depression Alleviation-Combined Treatment (YoDA-C) study is to determine whether antidepressant m..

Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients

M Lõpez-Solà, J Pujol, TD Wager, A Garcia-Fontanals, L Blanco-Hinojo, S Garcia-Blanco, V Poca-Dias, BJ Harrison, O Contreras-Rodríguez, J Monfort, F Garcia-Fructuoso, J Deus

2014-11-01

Objective Fibromyalgia (FM) is a disorder characterized by chronic pain and enhanced responses to acute noxious events. However, t..

Disruption of brain white matter microstructure in women with anorexia nervosa

E Via, A Zalesky, I Sánchez, L Forcano, BJ Harrison, J Pujol, F Fernández-Aranda, JM Menchón, C Soriano-Mas, N Cardoner, A Fornito

2014-11-01

Background: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its ..

Does motion-related brain functional connectivity reflect both artifacts and genuine neural activity?

J Pujol, D Macià, L Blanco-Hinojo, G Martínez-Vilavella, J Sunyer, R de la Torre, A Caixàs, R Martín-Santos, J Deus, BJ Harrison

2014-11-01

Imaging research on functional connectivity is uniquely contributing to characterize the functional organization of the human brai..

Large-scale brain network dynamics supporting adolescent cognitive control

DB Dwyer, BJ Harrison, M Yücel, S Whittle, A Zalesky, C Pantelis, NB Allen, A Fornito

2014-10-15

Adolescenceisatime when the ability to engage cognitive controlislinked to crucial life outcomes. Despiteahistorical focus onprefr..

Hoarding pet animals in obsessive-compulsive disorder

AL Campos-Lima, AR Torres, M Yücel, BJ Harrison, J Moll, GM Ferreira, LF Fontenelle

2014-10-02

Background Although severe hoarding symptoms have been considered rare among obsessive-compulsive disorder (OCD) samples, the prev..

Time-resolved resting-state brain networks

A Zalesky, A Fornito, L Cocchi, LL Gollo, M Breakspear

2014-07-15

Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation p..

Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis

O Dandash, A Fornito, J Lee, RSE Keefe, MWL Chee, RA Adcock, C Pantelis, SJ Wood, BJ Harrison

2014-01-01

Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal stri..

Amygdala activation and symptom dimensions in obsessive-compulsive disorder

E Via, N Cardoner, J Pujol, P Alonso, M López-Solà, E Real, O Contreras-Rodríguez, J Deus, C Segalàs, JM Menchón, C Soriano-Mas, BJ Harrison

2014-01-01

Background Despite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology of obsessive-com..

Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder

C Segalàs, P Alonso, A Orbegozo, E Real, M Subirà, C López-Solà, I Martínez-Zalacaín, J Labad, BJ Harrison, J Pujol, JM Menchón, N Cardoner, C Soriano-Mas

2014-01-01

Olfactory dysfunction has been described in obsessive-compulsive disorder (OCD). Brain regions involved in smell processing partia..

Disrupted neural processing of emotional faces in psychopathy

O Contreras-rodríguez, J Pujol, I Batalla, BJ Harrison, J Bosque, I Ibern-regàs, R Hernández-ribas, C Soriano-mas, J Deus, M López-solà, J Pifarré, JM Menchón, N Cardoner

2014-01-01

Psychopaths show a reduced ability to recognize emotion facial expressions, which may disturb the interpersonal relationship devel..

Functional brain imaging studies of youth depression: A systematic review

R Kerestes, CG Davey, K Stephanou, SL Whittle, BJ Harrison

2014-01-01

Background There is growing interest in understanding the neurobiology of major depressive disorder (MDD) in youth, particularly i..

Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users

J Pujol, L Blanco-Hinojo, A Batalla, M López-Solà, BJ Harrison, C Soriano-Mas, JA Crippa, AB Fagundo, J Deus, R De la Torre, S Nogué, M Farré, M Torrens, R Martín-Santos

2014-01-01

Background: Recreational drugs are generally used to intentionally alter conscious experience. Long-lasting cannabis users frequen..

Modulation of brain structure by catechol-O-methyltransferase Val 158Met polymorphism in chronic cannabis users

A Batalla, C Soriano-Mas, M Lõpez-Solà, M Torrens, JA Crippa, S Bhattacharyya, L Blanco-Hinojo, AB Fagundo, BJ Harrison, S Nogué, R De La Torre, M Farré, J Pujol, R Martín-Santos

2014-01-01

Neuroimaging studies have shown that chronic consumption of cannabis may result in alterations in brain morphology. Recent work fo..

Prevalence and heritability of obsessive-compulsive spectrum and anxiety disorder symptoms: A survey of the Australian twin registry

C López-Solà, LF Fontenelle, P Alonso, D Cuadras, DL Foley, C Pantelis, J Pujol, M Yücel, N Cardoner, C Soriano-Mas, JM Menchón, BJ Harrison

2014-01-01

While past twin studies indicate moderate levels of heritability of "obsessive-compulsive related" and anxiety disorder symptoms, ..

The contribution of sensory system functional connectivity reduction to clinical pain in fibromyalgia

J Pujol, D Macià, A Garcia-Fontanals, L Blanco-Hinojo, M López-Solà, S Garcia-Blanco, V Poca-Dias, BJ Harrison, O Contreras-Rodríguez, J Monfort, F Garcia-Fructuoso, J Deus

2014-01-01

Fibromyalgia typically presents with spontaneous body pain with no apparent cause and is considered pathophysiologically to be a f..

The psychiatric facet of hyperhidrosis: Demographics, disability, quality of life, and associated psychopathology

LDR Lessa, FB Luz, RM De Rezende, SM Durães, BJ Harrison, GB De Menezes, LF Fontenelle

2014-01-01

We compared the sociodemographic and psychiatric features of treatment-seeking patients with (n=17) and without (n=29) primary hyp..

Neural correlates of obsessive-compulsive related dysfunctional beliefs

P Alonso, A Orbegozo, J Pujol, C López-Solà, MA Fullana, C Segalàs, E Real, M Subirà, I Martínez-Zalacaín, JM Menchón, BJ Harrison, N Cardoner, C Soriano-Mas

2013-12-02

There have been few attempts to integrate neurobiological and cognitive models of obsessive-compulsive disorder (OCD), although th..

Cognitive impairment in euthymic major depressive disorder: A meta-analysis

E Bora, BJ Harrison, M Yücel, C Pantelis

2013-10-01

Background There is evidence to suggest that cognitive deficits might persist beyond the acute stages of illness in major depressi..

Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive Obsessions

M Subirà, P Alonso, C Segalàs, E Real, C López-Solà, J Pujol, I Martínez-Zalacaín, BJ Harrison, JM Menchón, N Cardoner, C Soriano-Mas

2013-09-30

Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consi..

Structural covariance of the neostriatum with regional gray matter volumes

C Soriano-Mas, BJ Harrison, J Pujol, M López-Solà, R Hernández-Ribas, P Alonso, O Contreras-Rodríguez, M Giménez, L Blanco-Hinojo, H Ortiz, J Deus, JM Menchón, N Cardoner

2013-05-01

The caudate and putamen nuclei have been traditionally divided into dorsal and ventral territories based on their segregated patte..

Neural response to the observable self in social anxiety disorder

J Pujol, M Giménez, H Ortiz, C Soriano-Mas, M López-Sola, M Farré, J Deus, E Merlo-Pich, BJ Harrison, N Cardoner, R Navinés, R Martín-Santos

2013-04-01

Background Distorted images of the observable self are considered crucial in the development and maintenance of social anxiety. We..

Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder

BJ Harrison, J Pujol, N Cardoner, J Deus, P Alonso, M López-Solà, O Contreras-Rodríguez, E Real, C Segalàs, L Blanco-Hinojo, JM Menchon, C Soriano-Mas

2013-02-15

Background: Functional neuroimaging studies have provided consistent support for the idea that obsessive-compulsive disorder (OCD)..

Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis

A Fornito, BJ Harrison, E Goodby, A Dean, C Ooi, PJ Nathan, BR Lennox, PB Jones, J Suckling, ET Bullmore

2013-01-01

IMPORTANCE: Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology of psychotic disorders..

Hatred of sounds: Misophonic disorder or just an underreported psychiatric symptom?

GM Ferreira, BJ Harrison, LF Fontenelle

2013-01-01

BACKGROUND: Misophonia, or selective sound sensitivity syndrome, is a preoccupation with or aversion to certain types of sounds th..

Breakdown in the brain network subserving moral judgment in criminal psychopathy

J Pujol, I Batalla, O Contreras-Rodríguez, BJ Harrison, V Pera, R Hernández-Ribas, E Real, L Bosa, C Soriano-Mas, J Deus, M López-Solà, J Pifarré, JM Menchón, N Cardoner

2012-11-01

Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in norma..

Task-related deactivation and functional connectivity of the subgenual cingulate cortex in major depressive disorder

CG Davey, M Yücel, NB Allen, BJ Harrison

2012-10-04

Background: Major depressive disorder is associated with functional alterations in activity and resting-state connectivity of the ..

Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder

CG Davey, BJ Harrison, M Yücel, NB Allen

2012-10-01

Background Depression has been associated with functional alterations in several areas of the cingulate cortex. In this study we h..

Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection

A Fornito, BJ Harrison, A Zalesky, JS Simons

2012-07-31

Analyses of functional interactions between large-scale brain networks have identified two broad systems that operate in apparent ..

Functional connectivity in brain networks underlying cognitive control in chronic cannabis users

IH Harding, N Solowij, BJ Harrison, M Takagi, V Lorenzetti, DI Lubman, ML Seal, C Pantelis, M Yücel

2012-07-01

The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control a..

Neural correlates of moral sensitivity in obsessive-compulsive disorder

BJ Harrison, J Pujol, C Soriano-Mas, R Hernández-Ribas, M López-Solà, H Ortiz, P Alonso, J Deus, JM Menchon, E Real, C Segalàs, O Contreras-Rodríguez, L Blanco-Hinojo, N Cardoner

2012-07-01

Context: Heightened moral sensitivity seems to characterize patients with obsessive-compulsive disorder (OCD). Recent advances in ..

Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder

L Cocchi, BJ Harrison, J Pujol, IH Harding, A Fornito, C Pantelis, M Yücel

2012-05-01

Objectives: Neuroimaging studies have consistently implicated alterations of the basal ganglia and orbitofrontal cortex in the pat..

Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal- thalamic circuits in major depressive disorder

E Bora, BJ Harrison, CG Davey, M Yücel, C Pantelis

2012-04-01

Background Abnormalities in cortico-striatal-pallidal-thalamic (CSPT) circuits have been implicated in major depressive disorder (..

Towards a post-traumatic subtype of obsessive-compulsive disorder

LF Fontenelle, L Cocchi, BJ Harrison, RG Shavitt, MC do Rosário, YA Ferrão, MA de Mathis, AV Cordioli, M Yücel, C Pantelis, JDJ Mari, EC Miguel, AR Torres

2012-03-01

We evaluated whether traumatic events are associated with a distinctive pattern of socio-demographic and clinical features of obse..

Brain connectivity and mental illness.

Alex Fornito, Ben J Harrison

2012-01-01

Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder

LF Fontenelle, BJ Harrison, J Pujol, CG Davey, A Fornito, E Bora, C Pantelis, M Yücel

2012-01-01

Background: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining sympt..

White matter microstructure in opiate addiction

E Bora, M Yücel, A Fornito, C Pantelis, BJ Harrison, L Cocchi, G Pell, DI Lubman

2012-01-01

Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially ex..

Task-Induced deactivation from rest extends beyond the default mode brain network

BJ Harrison, J Pujol, O Contreras-Rodríguez, C Soriano-Mas, M López-Solà, J Deus, H Ortiz, L Blanco-Hinojo, P Alonso, R Hernández-Ribas, N Cardoner, JM Menchón

2011-08-03

Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional ne..

Enhanced brain responsiveness during active emotional face processing in obsessive compulsive disorder

N Cardoner, BJ Harrison, J Pujol, C Soriano-Mas, R Herńndez-Ribas, M López-Solá, E Real, J Deus, H Ortiz, P Alonso, JM Menchãn

2011-08-01

Objectives. The abnormal processing of emotional stimuli is common to a variety of psychiatric disorders. Specifically, patients w..

Variations in the shape of the frontobasal brain region in obsessive-compulsive disorder

J Pujol, C Soriano-Mas, JD Gispert, M Bossa, S Reig, H Ortiz, P Alonso, N Cardoner, M López-Solà, BJ Harrison, J Deus, JM Menchón, M Desco, S Olmos

2011-07-01

Obsessive-compulsive disorder (OCD) emerges during childhood through young adulthood coinciding with the late phases of postnatal ..

Obsessive-compulsive disorder, impulse control disorders and drug addiction: Common features and potential treatments

LF Fontenelle, S Oostermeijer, BJ Harrison, C Pantelis, M Ycel

2011-05-23

The basic concepts underlying compulsive, impulsive and addictive behaviours overlap, which may help explain why laymen use these ..

Increased amygdala response to positive social feedback in young people with major depressive disorder

CG Davey, NB Allen, BJ Harrison, M Ycel

2011-04-15

Background: Studies of depressed patients have demonstrated increased amygdala activation to negative affective stimuli. In this s..

Cross-sectional and longitudinal assessment of structural brain alterations in melancholic depression

C Soriano-Mas, R Hernndez-Ribas, J Pujol, M Urretavizcaya, J Deus, BJ Harrison, H Ortiz, M Lpez-Sol, JM Menchn, N Cardoner

2011-02-15

Background Whole-brain imaging approaches may contribute to the characterization of neuroanatomic alterations in major depression,..

Role of stressful and traumatic life events in obsessive-compulsive disorder

LF Fontenelle, L Cocchi, BJ Harrison, EC Miguel, AR Torres

2011-02-01

Whilst genetic factors are thought to contribute to the development of obsessive-compulsive disorder (OCD), the role of environmen..

White matter microstructure in patients with obsessive-compulsive disorder

E Bora, BJ Harrison, A Fornito, L Cocchi, J Pujol, LF Fontenelle, D Velakoulis, C Pantelis, M Yücel

2011-01-01

Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inc..

Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder

M López-Solà, J Pujol, R Hernández-Ribas, BJ Harrison, O Contreras-Rodríguez, C Soriano-Mas, J Deus, H Ortiz, JM Menchón, J Vallejo, N Cardoner

2010-10-01

Major depressive disorder (MDD) is characterized by a constellation of affective, cognitive, and somatic symptoms associated with ..